|Date: Friday, November 16, 2018
Location: 1084 East Hall (3:00 PM to 4:00 PM)
Title: Stochastic modeling of mutant clone propagation during carcinogenesis
Abstract: Carcinogenesis, the transformation from healthy tissue to invasive cancer, is characterized by the progressive accumulation of mutations in a small group of founder cells. This talk focuses on the spread of premalignant cells during the process of carcinogenesis in epithelial tissue, utilizing a spatial stochastic model of mutation accumulation and clonal expansion. We use this model to develop a measure of the length-scale of genetic heterogeneity during carcinogenesis. In addition, we study the rate of expansion of a mutant clone, and discuss the clinical implications that arise from differences in the underlying structure of the tissue.
Speaker: Katie Storey
Institution: University of Michigan
Event Organizer: Charlie Doering firstname.lastname@example.org