Seminar Event Detail

Applied Interdisciplinary Mathematics (AIM)

Date:  Friday, November 16, 2018
Location:  1084 East Hall (3:00 PM to 4:00 PM)

Title:  Stochastic modeling of mutant clone propagation during carcinogenesis

Abstract:   Carcinogenesis, the transformation from healthy tissue to invasive cancer, is characterized by the progressive accumulation of mutations in a small group of founder cells. This talk focuses on the spread of premalignant cells during the process of carcinogenesis in epithelial tissue, utilizing a spatial stochastic model of mutation accumulation and clonal expansion. We use this model to develop a measure of the length-scale of genetic heterogeneity during carcinogenesis. In addition, we study the rate of expansion of a mutant clone, and discuss the clinical implications that arise from differences in the underlying structure of the tissue.


Speaker:  Katie Storey
Institution:  University of Michigan

Event Organizer:   Charlie Doering


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